A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable.

Jensen KL, Russell P

Homologous recombination (HR) repair of programmed meiotic double-strand breaks (DSBs) requires endonucleolytic clipping of Rec12(Spo11)-oligonucleotides from 5' DNA ends followed by resection to generate invasive 3' single-stranded DNA tails. The Mre11-Rad50-Nbs1 (MRN) endonuclease and Ctp1 (CtIP and Sae2 ortholog) are required for both activities in fission yeast but whether they are genetically separable is controversial. Here, we investigate the mitotic ... [more]

Nucleic Acids Res. Sep. 30, 2016; 44(17);8241-9 [Pubmed: 27325741]

Throughput

Low Throughput

Ontology Terms

phenotype: viability (APO:0000111)
phenotype: resistance to chemicals (APO:0000087)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
EXO1 CTP1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Ryan CJ (2012)	High	-6.1566	BioGRID	791758
EXO1 CTP1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Langerak P (2011)	Low	-	BioGRID	561883

Curated By

BioGRID

Interaction Summary

CTP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

endonuclease activity [ISO]

Gene Ontology Cellular Component

EXO1