BAIT
ARF1
RP23-192P17.1
ADP-ribosylation factor 1
GO Process (18)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- Golgi to transport vesicle transport [ISO]
- actin filament organization [ISO]
- cellular copper ion homeostasis [ISO]
- dendritic spine organization [ISO]
- long term synaptic depression [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of late endosome to lysosome transport [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- protein transport [TAS]
- regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- regulation of receptor internalization [ISO]
- synaptic vesicle budding [ISO]
- very-low-density lipoprotein particle assembly [ISO]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARHGAP21
5530401C11Rik, AA416458, ARHGAP10, RP23-436G18.3
Rho GTPase activating protein 21
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.
ARHGAP21 is a Rho family GTPase-activating protein (RhoGAP) that controls the Arp2/3 complex and F-actin dynamics at the Golgi complex by regulating the activity of the small GTPase Cdc42. ARHGAP21 is recruited to the Golgi by binding to another small GTPase, ARF1. Here, we present the crystal structure of the activated GTP-bound form of ARF1 in a complex with the ... [more]
EMBO J. Apr. 04, 2007; 26(7);1953-62 [Pubmed: 17347647]
Throughput
- Low Throughput
Curated By
- BioGRID