BAIT

DDI2

YFL061W
Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants
GO Process (0)
GO Function (0)
GO Component (0)
Saccharomyces cerevisiae (S288c)
PREY

DDI2

YFL061W
Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants
GO Process (0)
GO Function (0)
GO Component (0)
Saccharomyces cerevisiae (S288c)

Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structure of Ddi2, a Highly Inducible Detoxifying Metalloenzyme from S. cerevisiae.

Li J, Jia Y, Lin A, Hanna M, Chelico L, Xiao W, Moore SA

Cyanamide (H2N-CN) is used to break bud dormancy in woody plants and to deter alcohol use in humans. The biological effects of cyanamide in both these cases require the enzyme catalase. We previously demonstrated that Saccharomyces cerevisiae exposed to cyanamide resulted in strong induction of DDI2 gene expression. Ddi2 enzymatically hydrates cyanamide to urea, and belongs to the family of ... [more]

J. Biol. Chem. May. 31, 2019; (); [Pubmed: 31152065]

Throughput

  • Low Throughput

Additional Notes

  • dimer

Curated By

  • BioGRID