BAIT
MYD88
myeloid differentiation primary response gene 88
GO Process (31)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- JNK cascade [ISO]
- MyD88-dependent toll-like receptor signaling pathway [IGI, IMP]
- Toll signaling pathway [ISO]
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [ISO]
- defense response to Gram-positive bacterium [IMP]
- establishment of endothelial intestinal barrier [IMP]
- immune response [TAS]
- immunoglobulin mediated immune response [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of growth of symbiont in host [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-23 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of tumor necrosis factor production [IGI, IMP]
- regulation of cell proliferation [IGI]
- regulation of inflammatory response [IMP]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IGI, IMP]
- response to molecule of fungal origin [IMP]
- response to peptidoglycan [IMP]
- response to virus [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- type I interferon biosynthetic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.
Toll-like receptors (TLRs) recognize various pathogen- and host tissue-derived molecules and initiate inflammatory immune responses. Exaggerated or prolonged TLR activation, however, can lead to etiologically diverse diseases, such as bacterial sepsis, metabolic and autoimmune diseases, or stroke. Despite the apparent medical need, no small-molecule drugs against TLR pathways are clinically available. This may be because of the complex signaling mechanisms ... [more]
Sci Signal Aug. 14, 2018; 11(543); [Pubmed: 30108181]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID