BAIT
TLR9
toll-like receptor 9
GO Process (35)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISO]
- defense response to Gram-negative bacterium [ISO]
- defense response to virus [IGI, ISO]
- immune response [IMP]
- innate immune response [TAS]
- maintenance of gastrointestinal epithelium [IMP]
- microglial cell activation [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of toll-like receptor signaling pathway [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of chemokine production [ISO]
- positive regulation of interferon-alpha biosynthetic process [ISO]
- positive regulation of interferon-beta biosynthetic process [ISO]
- positive regulation of interferon-beta production [IDA]
- positive regulation of interferon-gamma biosynthetic process [ISO]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-18 production [IDA]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of toll-like receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of B cell activation [IGI]
- regulation of inflammatory response [IMP]
- response to molecule of bacterial origin [TAS]
- response to virus [IMP]
- toll-like receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYD88
myeloid differentiation primary response gene 88
GO Process (31)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- JNK cascade [ISO]
- MyD88-dependent toll-like receptor signaling pathway [IGI, IMP]
- Toll signaling pathway [ISO]
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [ISO]
- defense response to Gram-positive bacterium [IMP]
- establishment of endothelial intestinal barrier [IMP]
- immune response [TAS]
- immunoglobulin mediated immune response [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of growth of symbiont in host [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-23 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of tumor necrosis factor production [IGI, IMP]
- regulation of cell proliferation [IGI]
- regulation of inflammatory response [IMP]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IGI, IMP]
- response to molecule of fungal origin [IMP]
- response to peptidoglycan [IMP]
- response to virus [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- type I interferon biosynthetic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.
Toll-like receptors (TLRs) recognize various pathogen- and host tissue-derived molecules and initiate inflammatory immune responses. Exaggerated or prolonged TLR activation, however, can lead to etiologically diverse diseases, such as bacterial sepsis, metabolic and autoimmune diseases, or stroke. Despite the apparent medical need, no small-molecule drugs against TLR pathways are clinically available. This may be because of the complex signaling mechanisms ... [more]
Sci Signal Aug. 14, 2018; 11(543); [Pubmed: 30108181]
Throughput
- Low Throughput
Curated By
- BioGRID