LILRB1
Gene Ontology Biological Process
- Fc receptor mediated inhibitory signaling pathway [IDA]
- T cell proliferation involved in immune response [IDA]
- cellular response to lipopolysaccharide [IEP]
- defense response to virus [IDA]
- dendritic cell differentiation [IEP]
- immune response-inhibiting cell surface receptor signaling pathway [NAS]
- interferon-gamma production [IDA]
- interferon-gamma secretion [IDA]
- negative regulation of CD8-positive, alpha-beta T cell activation [IDA]
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [IDA]
- negative regulation of T cell mediated cytotoxicity [IDA]
- negative regulation of T cell proliferation [IDA]
- negative regulation of alpha-beta T cell activation [IDA]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of dendritic cell differentiation [IMP]
- negative regulation of endocytosis [IDA]
- negative regulation of interferon-beta secretion [IDA]
- negative regulation of interferon-gamma biosynthetic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-10 secretion [IDA]
- negative regulation of interleukin-12 secretion [IDA]
- negative regulation of mononuclear cell proliferation [IDA]
- negative regulation of natural killer cell mediated cytotoxicity [IDA]
- negative regulation of osteoclast development [IDA]
- negative regulation of serotonin secretion [IDA]
- negative regulation of transforming growth factor-beta secretion [IDA]
- negative regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cytolysis [IDA, IMP]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of gamma-delta T cell activation involved in immune response [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of transcription from RNA polymerase II promoter [NAS]
- receptor internalization [TAS]
- regulation of immune response [TAS]
- response to virus [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HLA-G
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular defense response [TAS]
- cytokine-mediated signaling pathway [TAS]
- immune response-inhibiting cell surface receptor signaling pathway [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of T cell proliferation [IDA]
- negative regulation of dendritic cell differentiation [IDA]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of regulatory T cell differentiation [IMP]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) is expressed on a wider range of immune cells including subsets of natural killer and T cells. Both ILTs contain immunoreceptor tyrosine-based inhibitory receptor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID