VAMP7
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [ISS]
- autophagic vacuole fusion [IMP]
- calcium ion-dependent exocytosis [ISS]
- endocytosis [IBA]
- endosome to lysosome transport [IDA]
- eosinophil degranulation [IMP, ISS]
- exocytosis [IBA]
- membrane organization [TAS]
- natural killer cell degranulation [IMP]
- neutrophil degranulation [IMP, ISS]
- phagocytosis, engulfment [ISS]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- vesicle fusion [IDA]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- SNARE complex [IDA, ISS]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- endoplasmic reticulum membrane [ISS]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- lamellipodium [IDA]
- late endosome membrane [ISS]
- lysosomal membrane [IDA, ISS, TAS]
- membrane [IDA]
- neuron projection [ISS]
- phagocytic vesicle [ISS]
- plasma membrane [IDA, TAS]
- platelet alpha granule [IDA]
- pseudopodium [IDA]
- secretory granule [IDA]
- secretory granule membrane [IDA]
- trans-Golgi network [IDA]
SNAP25
Gene Ontology Biological Process
- energy reserve metabolic process [TAS]
- glutamate secretion [TAS]
- neurotransmitter secretion [TAS]
- neurotransmitter uptake [NAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [NAS, TAS]
- synaptic vesicle docking [NAS]
- synaptic vesicle exocytosis [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A dual mechanism controlling the localization and function of exocytic v-SNAREs.
SNARE [soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor] proteins are essential for membrane fusion but their regulation is not yet fully understood. We have previously shown that the amino-terminal Longin domain of the v-SNARE TI-VAMP (tetanus neurotoxin-insensitive vesicle-associated membrane protein)/VAMP7 plays an inhibitory role in neurite outgrowth. The goal of this study was to investigate the regulation of TI-VAMP as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID