BAIT
MDC1
NFBD1, DAAP-285E11.7
mediator of DNA-damage checkpoint 1
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH13
CDHH, P105
cadherin 13
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- Rho protein signal transduction [IMP]
- adherens junction organization [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- endothelial cell migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- keratinocyte proliferation [IDA]
- lamellipodium assembly [IDA]
- localization within membrane [IMP]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of endocytosis [IMP]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1. Our spatially resolved interaction maps reveal rich network intricacies, identify shared and bait-specific interaction modules, and implicate ... [more]
Cell Dec. 03, 2017; 173(4);972-988.e23 [Pubmed: 29656893]
Throughput
- High Throughput
Curated By
- BioGRID