GLI2
Gene Ontology Biological Process
- axon guidance [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell proliferation [IDA]
- cellular response to virus [IDA]
- cerebellar cortex morphogenesis [ISS]
- developmental growth [ISS]
- embryonic digestive tract development [ISS]
- epidermal cell differentiation [IDA]
- floor plate formation [ISS]
- heart development [ISS]
- hindbrain development [ISS]
- hindgut morphogenesis [ISS]
- kidney development [ISS]
- lung development [ISS]
- mammary gland development [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- neuron development [ISS]
- odontogenesis of dentin-containing tooth [ISS]
- osteoblast development [ISS]
- osteoblast differentiation [IDA]
- pattern specification process [ISS]
- pituitary gland development [ISS]
- positive regulation of DNA replication [IDA]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- proximal/distal pattern formation [ISS]
- skeletal system development [ISS]
- smoothened signaling pathway [IDA]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [ISS]
- spinal cord dorsal/ventral patterning [ISS]
- spinal cord ventral commissure morphogenesis [ISS]
- tube development [ISS]
- ventral midline development [ISS]
- ventral spinal cord development [ISS]
Gene Ontology Molecular Function
BTRC
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [TAS]
- negative regulation of smoothened signaling pathway [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of proteolysis [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein dephosphorylation [ISS]
- protein destabilization [IMP]
- protein ubiquitination [IDA]
- regulation of circadian rhythm [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- signal transduction [TAS]
- ubiquitin-dependent protein catabolic process [IDA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3.
Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and progression, there is little indication that Smo is involved. Here we describe a non-canonical ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of BTRC not clear
Curated By
- BioGRID