CHEK1
Gene Ontology Biological Process
- DNA damage checkpoint [ISO, ISS]
- DNA damage induced protein phosphorylation [IMP, ISO]
- DNA repair [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to caffeine [IEP]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic substance [IEP]
- chromatin-mediated maintenance of transcription [ISO, ISS]
- histone H3-T11 phosphorylation [ISO]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of mitosis [ISO, ISS]
- peptidyl-threonine phosphorylation [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- regulation of cell proliferation [ISO]
- regulation of double-strand break repair via homologous recombination [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of histone H3-K9 acetylation [ISO, ISS]
- regulation of mitotic centrosome separation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERRFI1
Gene Ontology Biological Process
- lung alveolus development [ISO, ISS]
- lung epithelium development [ISO, ISS]
- lung vasculature development [ISO, ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of epidermal growth factor-activated receptor activity [IDA, ISO, ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA, ISS]
- negative regulation of protein autophosphorylation [ISO, ISS]
- regulation of keratinocyte differentiation [ISO, ISS]
- skin morphogenesis [ISO, ISS]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.
Receptor-associated late transducer (RALT) acts as a negative feedback inhibitor of ErbB receptor signaling via physical interaction with ErbB. Although RALT contains a 14-3-3 binding motif (247-RSHSGP-252), little is known about the molecular basis and significance of binding to 14-3-3. Here, we report that 14-3-3 interacts with RALT in H9c2 and COS-7 cells in a Ser-250 phosphorylation-dependent manner. An in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID