NRP1
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [IMP]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [IMP]
- angiogenesis [IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [IMP]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- cell migration [IMP]
- cell migration involved in coronary vasculogenesis [IC]
- cell migration involved in sprouting angiogenesis [IC, IMP]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- commissural neuron axon guidance [IMP]
- coronary artery morphogenesis [IMP]
- dendrite development [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IGI, IMP]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [IGI]
- negative regulation of axon extension involved in axon guidance [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- protein localization to early endosome [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- regulation of retinal ganglion cell axon guidance [IMP]
- renal artery morphogenesis [IMP]
- retina vasculature morphogenesis in camera-type eye [IMP]
- retinal ganglion cell axon guidance [IMP]
- semaphorin-plexin signaling pathway [IDA, IGI, IPI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sprouting angiogenesis [IMP]
- sympathetic ganglion development [IMP]
- sympathetic nervous system development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
- toxin transport [IMP]
- trigeminal nerve morphogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FLT1
Gene Ontology Biological Process
- angiogenesis [IMP, TAS]
- blood vessel morphogenesis [IMP]
- cell migration [IGI, IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- embryonic morphogenesis [IMP]
- monocyte chemotaxis [ISO]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of hematopoietic progenitor cell differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- protein autophosphorylation [ISO]
- response to hypoxia [IMP]
- sprouting angiogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IC, IMP, ISO]
- vascular endothelial growth factor receptor-1 signaling pathway [ISO]
- vascular endothelial growth factor signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1.
Neuropilin-1 (NP-1) was first identified as a semaphorin receptor involved in neuron guidance. Subsequent studies demonstrated that NP-1 also binds an isoform of vascular endothelial growth factor (VEGF) as well as several VEGF homologs, suggesting that NP-1 may also function in angiogenesis. Here we report in vitro binding experiments that shed light on the interaction between VEGF165 and NP-1, as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID