BAIT
NRP1
C530029I03, NP-1, NPN-1, Npn1, Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [IMP]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [IMP]
- angiogenesis [IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [IMP]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- cell migration [IMP]
- cell migration involved in coronary vasculogenesis [IC]
- cell migration involved in sprouting angiogenesis [IC, IMP]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- commissural neuron axon guidance [IMP]
- coronary artery morphogenesis [IMP]
- dendrite development [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IGI, IMP]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [IGI]
- negative regulation of axon extension involved in axon guidance [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- protein localization to early endosome [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- regulation of retinal ganglion cell axon guidance [IMP]
- renal artery morphogenesis [IMP]
- retina vasculature morphogenesis in camera-type eye [IMP]
- retinal ganglion cell axon guidance [IMP]
- semaphorin-plexin signaling pathway [IDA, IGI, IPI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sprouting angiogenesis [IMP]
- sympathetic ganglion development [IMP]
- sympathetic nervous system development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
- toxin transport [IMP]
- trigeminal nerve morphogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FLT1
AI323757, Flt-1, VEGFR-1, VEGFR1, sFlt1
FMS-like tyrosine kinase 1
GO Process (23)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [IMP, TAS]
- blood vessel morphogenesis [IMP]
- cell migration [IGI, IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- embryonic morphogenesis [IMP]
- monocyte chemotaxis [ISO]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of hematopoietic progenitor cell differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- protein autophosphorylation [ISO]
- response to hypoxia [IMP]
- sprouting angiogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IC, IMP, ISO]
- vascular endothelial growth factor receptor-1 signaling pathway [ISO]
- vascular endothelial growth factor signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1.
Neuropilin-1 (NP-1) was first identified as a semaphorin receptor involved in neuron guidance. Subsequent studies demonstrated that NP-1 also binds an isoform of vascular endothelial growth factor (VEGF) as well as several VEGF homologs, suggesting that NP-1 may also function in angiogenesis. Here we report in vitro binding experiments that shed light on the interaction between VEGF165 and NP-1, as ... [more]
J. Biol. Chem. Sep. 01, 2000; 275(35);26690-5 [Pubmed: 10842181]
Throughput
- Low Throughput
Curated By
- BioGRID