BAIT
LTN1
C21orf10, C21orf98, RNF160, ZNF294, HSPC087
listerin E3 ubiquitin protein ligase 1
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
ACACA
ACAC, ACACAD, ACC, ACC1, ACCA
acetyl-CoA carboxylase alpha
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISS]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- fatty acid biosynthetic process [ISS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.
Previous genetic and biochemical studies from Saccharomyces cerevisiae have identified a critical ribosome-associated quality control complex (RQC) that facilitates resolution of stalled ribosomal complexes. While components of the mammalian RQC have been examined in vitro, a systematic characterization of RQC protein interactions in mammalian cells has yet to be described. Here we utilize both proximity-labeling proteomic approaches, BioID and APEX, ... [more]
Mol. Biol. Cell Dec. 15, 2017; 29(10);1258-1269 [Pubmed: 29540532]
Throughput
- High Throughput
Additional Notes
- The 'hit' protein was identified by mass spectrometry in either an APEX-based or a BioID-based proximity label experiment.
Curated By
- BioGRID