Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

PI5P4KÎ³ functions in DTX1-mediated Notch signaling.

Zheng L, Conner SD

Notch signaling is an evolutionarily conserved pathway that is essential for development, where it controls processes ranging from cell differentiation to survival. Transport through endosomes is a critical step in regulating Notch signaling capacity, where the E3 ubiquitin ligase DTX1 is thought to control Notch1 intracellular transport decisions by direct receptor ubiquitination. However, how DTX1 regulates Notch1 transport within endosomes ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2017; 115(9);E1983-E1990 [Pubmed: 29440432]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PIP4K2A

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol-4-phosphate 5-kinase activity [NAS]

Gene Ontology Cellular Component

RAB4A