BAIT
NRP1
BDCA4, CD304, NP1, NRP, VEGF165R, RP11-342D11.1
neuropilin 1
GO Process (43)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- angiogenesis [IMP, ISS]
- angiogenesis involved in coronary vascular morphogenesis [ISS]
- artery morphogenesis [ISS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- axonogenesis involved in innervation [ISS]
- cell migration involved in sprouting angiogenesis [ISS]
- cell-cell signaling [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [ISS]
- commissural neuron axon guidance [ISS]
- endothelial cell chemotaxis [IMP]
- endothelial tip cell fate specification [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- organ morphogenesis [TAS]
- patterning of blood vessels [ISS]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of cytokine activity [TAS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of smooth muscle cell migration [TAS]
- protein localization to early endosome [ISS]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of vesicle-mediated transport [TAS]
- retina vasculature morphogenesis in camera-type eye [ISS]
- retinal ganglion cell axon guidance [ISS]
- semaphorin-plexin signaling pathway [NAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SEMA3A
COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
GO Process (15)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- axon extension involved in axon guidance [ISS]
- axon guidance [TAS]
- axonogenesis involved in innervation [ISS]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- olfactory bulb development [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- semaphorin-plexin signaling pathway [TAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- sensory system development [TAS]
- sympathetic ganglion development [ISS]
- sympathetic nervous system development [TAS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165.
Neuropilin-1 (Npn-1) is a receptor for both semaphorin 3A (Sema3A) and vascular endothelial growth factor 165 (VEGF(165)). To understand the role Npn-1 plays as a receptor for these structurally and functionally unrelated ligands, we set out to identify structural features of Npn-1 that confer binding to Sema3A or VEGF(165). We constructed Npn-1 variants containing deletions within the "a" and "b" ... [more]
J. Biol. Chem. May. 17, 2002; 277(20);18069-76 [Pubmed: 11886873]
Throughput
- Low Throughput
Curated By
- BioGRID