KMT2A
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- embryonic hemopoiesis [TAS]
- histone H3-K4 methylation [IDA, IMP]
- histone H3-K4 trimethylation [IDA]
- histone H4-K16 acetylation [IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transporter activity [IMP]
- protein complex assembly [IDA]
- regulation of histone H3-K14 acetylation [ISS]
- regulation of histone H3-K9 acetylation [ISS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
CTBP1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- negative regulation of cell proliferation [TAS]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of histone deacetylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell cycle [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.
The MLL (mixed-lineage leukemia) gene is involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia. We previously identified a transcriptional repression domain in MLL, which contains a region with homology to DNA methyltransferase. In chromosomal translocations, the MLL repression domain is retained in the leukemogenic fusion protein and is required for transforming activity of MLL fusion proteins. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KMT2A CTBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID