BAIT
KIAA1429
fSAP121, MSTP054
KIAA1429
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
CPEB3
RP11-430L14.3
cytoplasmic polyadenylation element binding protein 3
GO Process (14)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA destabilization [IDA]
- cellular response to amino acid stimulus [IDA, ISS]
- long-term memory [ISS]
- negative regulation of cytoplasmic translational elongation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of translation [IDA]
- positive regulation of dendritic spine development [ISS]
- positive regulation of mRNA polyadenylation [ISS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IDA]
- positive regulation of translation [ISS]
- regulation of dendritic spine development [ISS]
- regulation of synaptic plasticity [ISS]
- translation [IDA, ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
N6-methyladenosine (m6A) is enriched in 3'untranslated region (3'UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however. Herein we report a characterization of the full m6A methyltransferase complex in HeLa cells identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and we ... [more]
Cell Discov Mar. 07, 2018; 4();10 [Pubmed: 29507755]
Throughput
- High Throughput
Additional Notes
- The RNA of the 'hit' genes was identified in an RIP-seq (RNA immunoprecipitation sequencing) experiment using the 'bait' protein, VIRMA.
Curated By
- BioGRID