BAIT
KIAA1429
fSAP121, MSTP054
KIAA1429
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
WWC1
HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
WW and C2 domain containing 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell migration [IDA]
- establishment of cell polarity [TAS]
- hippo signaling [TAS]
- negative regulation of hippo signaling [IDA]
- negative regulation of organ growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of MAPK cascade [IDA]
- regulation of hippo signaling [IMP]
- regulation of intracellular transport [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
N6-methyladenosine (m6A) is enriched in 3'untranslated region (3'UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however. Herein we report a characterization of the full m6A methyltransferase complex in HeLa cells identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and we ... [more]
Cell Discov Mar. 07, 2018; 4();10 [Pubmed: 29507755]
Throughput
- High Throughput
Additional Notes
- The RNA of the 'hit' genes was identified in an RIP-seq (RNA immunoprecipitation sequencing) experiment using the 'bait' protein, VIRMA.
Curated By
- BioGRID