BAIT
NCOR2
N-CoR, SMRT, SMRTe
nuclear receptor co-repressor 2
GO Process (13)
GO Function (14)
GO Component (8)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI, IMP]
- cell proliferation in forebrain [IMP]
- forebrain development [IMP]
- glucose homeostasis [IMP]
- heart morphogenesis [IGI, IMP]
- in utero embryonic development [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of protein deacetylation [IDA]
- regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter [ISO]
- telencephalon development [IMP]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- Notch binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA, ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription corepressor activity [IDA, IGI, IMP, ISO]
- DNA binding [IDA]
- Notch binding [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA, ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription corepressor activity [IDA, IGI, IMP, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PIN1
0610025L01Rik, D9Bwg1161e
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
GO Process (14)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell motility [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein peptidyl-prolyl isomerization [ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [IMP, ISO]
- regulation of pathway-restricted SMAD protein phosphorylation [ISO]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT.
Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT phosphorylation. Pin1 ... [more]
J. Cell Biol. Oct. 06, 2008; 183(1);49-61 [Pubmed: 18838553]
Throughput
- Low Throughput
Curated By
- BioGRID