BAIT

WTAP

Mum2, RP1-56L9.4
Wilms tumor 1 associated protein
GO Process (2)
GO Function (0)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

TPM1

C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
tropomyosin 1 (alpha)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

Yue Y, Liu J, Cui X, Cao J, Luo G, Zhang Z, Cheng T, Gao M, Shu X, Ma H, Wang F, Wang X, Shen B, Wang Y, Feng X, He C, Liu J

N6-methyladenosine (m6A) is enriched in 3'untranslated region (3'UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however. Herein we report a characterization of the full m6A methyltransferase complex in HeLa cells identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and we ... [more]

Cell Discov Mar. 07, 2018; 4();10 [Pubmed: 29507755]

Throughput

  • High Throughput

Additional Notes

  • The 'hit' protein was identified in an IP (immunoprecipitation) of WTAP but not in IPs of METTL3 or METTL14.

Curated By

  • BioGRID