BAIT
DISC1
C1orf136, SCZD9, RP4-730B13.1
disrupted in schizophrenia 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COL4A1
BSVD, RP11-472K17.2
collagen, type IV, alpha 1
GO Process (10)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- axon guidance [TAS]
- basement membrane organization [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- patterning of blood vessels [IMP]
- renal tubule morphogenesis [IMP]
- retinal blood vessel morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Disrupted-In-Schizophrenia 1 (DISC1) is a novel gene associated with schizophrenia by multiple genetic studies. In order to determine how mutations in DISC1 might cause susceptibility to schizophrenia, we undertook a comprehensive study of the cellular biology of DISC1 in its full-length and disease-associated mutant forms. DISC1 interacts by yeast two-hybrid, mammalian two-hybrid, and co-immunoprecipitation assays with multiple proteins of the ... [more]
Hum. Mol. Genet. Jul. 01, 2003; 12(13);1591-608 [Pubmed: 12812986]
Throughput
- Low Throughput
Curated By
- BioGRID