BAIT

PSME3

HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
GO Process (24)
GO Function (4)
GO Component (6)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ.

Jonik-Nowak B, Menneteau T, Fesquet D, Baldin V, Bonne-Andrea C, Mechali F, Fabre B, Boisguerin P, de Rossi S, Henriquet C, Pugniere M, Ducoux-Petit M, Burlet-Schiltz O, Lamond AI, Fort P, Boulon S, Bousquet MP, Coux O

PA28γ is a nuclear activator of the 20S proteasome involved in the regulation of several essential cellular processes, such as cell proliferation, apoptosis, nuclear dynamics, and cellular stress response. Unlike the 19S regulator of the proteasome, which specifically recognizes ubiquitylated proteins, PA28γ promotes the degradation of several substrates by the proteasome in an ATP- and ubiquitin-independent manner. However, its exact ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 10, 2017; 115(28);E6477-E6486 [Pubmed: 29934401]

Throughput

  • High Throughput

Additional Notes

  • assayed using SILAC (stable isotope labeling by/with amino acids in cell culture)-based quantitative immunoprecipitation

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CAPZB PSME3
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
3350108

Curated By

  • BioGRID