BAIT
HMO1
HSM2, L000003234, YDR174W
Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia
GO Process (6)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- DNA packaging [IDA]
- chromatin organization involved in regulation of transcription [IDA]
- dsDNA loop formation [IDA]
- regulation of ribosomal protein gene transcription from RNA polymerase II promoter [IGI, IMP]
- regulation of transcription from RNA polymerase I promoter [IGI, IMP]
- transcriptional start site selection at RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
RPA12
RRN4, DNA-directed RNA polymerase I core subunit RPA12, A12.2, L000001672, YJR063W
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription.
Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III, and II is a key requirement for growth control. Using a novel global genetic approach, we showed that the absence of Hmo1 becomes lethal when combined with mutations of components of either ... [more]
Mol. Cell. Biol. Nov. 01, 2007; 27(22);8015-26 [Pubmed: 17875934]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID