HMO1
Gene Ontology Biological Process
- DNA packaging [IDA]
- chromatin organization involved in regulation of transcription [IDA]
- dsDNA loop formation [IDA]
- regulation of ribosomal protein gene transcription from RNA polymerase II promoter [IGI, IMP]
- regulation of transcription from RNA polymerase I promoter [IGI, IMP]
- transcriptional start site selection at RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
RPS6B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription.
Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III, and II is a key requirement for growth control. Using a novel global genetic approach, we showed that the absence of Hmo1 becomes lethal when combined with mutations of components of either ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Slow growth (ss)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HMO1 RPS6B | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1693 | BioGRID | 367648 | |
| RPS6B HMO1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1693 | BioGRID | 358907 | |
| HMO1 RPS6B | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1565 | BioGRID | 2096800 |
Curated By
- BioGRID