LRRC1
MUSK
Gene Ontology Biological Process
- extracellular matrix organization [TAS]
- memory [ISS]
- neuromuscular junction development [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of protein geranylgeranylation [ISS]
- positive regulation of protein phosphorylation [ISS]
- protein autophosphorylation [ISS]
- regulation of synaptic growth at neuromuscular junction [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction.
Erbin, a binding partner of ErbB2, was identified as the first member of the LAP family of proteins. Erbin was shown at postsynaptic membranes of the neuromuscular junction (NMJ) or in cultured C2C12 myotubes (1) to be concentrated, (2) to regulate the Ras-Raf-Mek pathway, and (3) to inhibit TGF-beta signaling. In the CNS, Erbin interacts with PSD-95. Furthermore, agrin-MuSK signaling ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID