SIRPA
Gene Ontology Biological Process
Gene Ontology Cellular Component
TBX3
Gene Ontology Biological Process
- anterior/posterior axis specification, embryo [IMP]
- cell aging [IDA]
- cellular senescence [IDA]
- embryonic digit morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- female genitalia development [IMP]
- follicle-stimulating hormone secretion [IMP]
- forelimb morphogenesis [IDA]
- luteinizing hormone secretion [IMP]
- male genitalia development [IMP]
- mammary gland development [IMP]
- mesoderm morphogenesis [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IDA]
- positive regulation of cell cycle [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- skeletal system development [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.
Tyrosine phosphatase non-receptor type substrate-1 (SHPS-1), a transmembrane protein, plays a vital role in cell migration and proliferation. Our previous studies have shown that insulin-like growth factor-I (IGF-I) stimulates SHPS-1 phosphorylation, leading to recruitment of SHP-2, c-Src, Shc, and Grb2.p85 to phosphorylated SHPS-1. Assembly of this signaling complex is required for optimal stimulation of both mitogen-activated protein and phosphatidylinositol 3-kinase ... [more]
Throughput
- High Throughput
Curated By
- BioGRID