BAIT
SIRPA
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, RP4-684O24.2
signal-regulatory protein alpha
GO Process (3)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
TBX3
TBX3-ISO, UMS, XHL
T-box 3
GO Process (21)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- anterior/posterior axis specification, embryo [IMP]
- cell aging [IDA]
- cellular senescence [IDA]
- embryonic digit morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- female genitalia development [IMP]
- follicle-stimulating hormone secretion [IMP]
- forelimb morphogenesis [IDA]
- luteinizing hormone secretion [IMP]
- male genitalia development [IMP]
- mammary gland development [IMP]
- mesoderm morphogenesis [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IDA]
- positive regulation of cell cycle [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- skeletal system development [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.
Tyrosine phosphatase non-receptor type substrate-1 (SHPS-1), a transmembrane protein, plays a vital role in cell migration and proliferation. Our previous studies have shown that insulin-like growth factor-I (IGF-I) stimulates SHPS-1 phosphorylation, leading to recruitment of SHP-2, c-Src, Shc, and Grb2.p85 to phosphorylated SHPS-1. Assembly of this signaling complex is required for optimal stimulation of both mitogen-activated protein and phosphatidylinositol 3-kinase ... [more]
Mol. Cell Proteomics Jul. 01, 2009; 8(7);1539-51 [Pubmed: 19299420]
Throughput
- High Throughput
Curated By
- BioGRID