BAIT
AMBRA1
DCAF3, WDR94
autophagy/beclin-1 regulator 1
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SLC25A13
ARALAR2, CITRIN, CTLN2
solute carrier family 25 (aspartate/glutamate carrier), member 13
GO Process (13)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ATP biosynthetic process [IDA]
- L-aspartate transmembrane transport [IDA]
- L-glutamate transmembrane transport [IDA]
- L-glutamate transport [IDA]
- aspartate transport [IDA]
- carbohydrate metabolic process [TAS]
- cellular respiration [IDA]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- malate-aspartate shuttle [IDA]
- response to calcium ion [IDA]
- small molecule metabolic process [TAS]
- transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
Multi-subunit cullin-RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4AMBRA1 (CRL substrate receptor denoted in superscript) targets Elongin C (ELOC), the essential adapter protein of CRL5 complexes, for polyubiquitination and degradation. We ... [more]
EMBO J. Sep. 14, 2018; 37(18); [Pubmed: 30166453]
Throughput
- High Throughput
Curated By
- BioGRID