PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
HSPD1
Gene Ontology Biological Process
- 'de novo' protein folding [ISS]
- ATP catabolic process [ISS]
- B cell activation [IDA]
- B cell cytokine production [IDA]
- B cell proliferation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- T cell activation [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- chaperone-mediated protein complex assembly [ISS]
- isotype switching to IgG isotypes [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell mediated immune response to tumor cell [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-gamma production [IDA, ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage activation [IDA]
- protein maturation [ISS]
- protein refolding [IDA]
- protein stabilization [IMP, ISS]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
Gene Ontology Cellular Component
- cell surface [IDA]
- coated pit [IDA]
- coated vesicle [IDA]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- lipopolysaccharide receptor complex [IDA]
- membrane [IDA]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- protein complex [IDA]
- secretory granule [ISS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.
Tyrosine phosphatase non-receptor type substrate-1 (SHPS-1), a transmembrane protein, plays a vital role in cell migration and proliferation. Our previous studies have shown that insulin-like growth factor-I (IGF-I) stimulates SHPS-1 phosphorylation, leading to recruitment of SHP-2, c-Src, Shc, and Grb2.p85 to phosphorylated SHPS-1. Assembly of this signaling complex is required for optimal stimulation of both mitogen-activated protein and phosphatidylinositol 3-kinase ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HSPD1 PTPN11 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3436895 |
Curated By
- BioGRID