BAIT
PTPN11
2700084A17Rik, AW536184, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, Syp
protein tyrosine phosphatase, non-receptor type 11
GO Process (41)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
GHR
GHBP, GHR/BP
growth hormone receptor
GO Process (27)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [IMP]
- JAK-STAT cascade [ISO]
- activation of JAK2 kinase activity [ISO]
- activation of Janus kinase activity [ISO]
- activation of MAPK activity [ISO]
- allantoin metabolic process [IMP]
- cellular response to hormone stimulus [ISO]
- citrate metabolic process [IMP]
- creatine metabolic process [IMP]
- creatinine metabolic process [IMP]
- cytokine-mediated signaling pathway [IDA, ISO]
- fatty acid metabolic process [IMP]
- growth hormone receptor signaling pathway [IDA, ISO]
- hormone-mediated signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- isoleucine metabolic process [IMP]
- multicellular organismal metabolic process [ISO]
- negative regulation of neuron death [ISO]
- oxaloacetate metabolic process [IMP]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of multicellular organism growth [IDA]
- response to estradiol [ISO]
- succinate metabolic process [IMP]
- taurine metabolic process [IMP]
- valine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- cytoplasm [ISO]
- extracellular space [ISO]
- extrinsic component of membrane [IDA]
- growth hormone receptor complex [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [ISO]
- mitochondrion [ISO]
- neuronal cell body [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association.
SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. Here we examine whether SIRPalpha and SHP-2 are signaling molecules for the receptors for growth hormone (GH), leukemia inhibitory factor (LIF), or interferon-gamma (IFNgamma), cytokine receptor superfamily members that bind to and ... [more]
J. Biol. Chem. Mar. 20, 1998; 273(12);7112-7 [Pubmed: 9507023]
Throughput
- Low Throughput
Curated By
- BioGRID