GHR
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [IMP]
- JAK-STAT cascade [ISO]
- activation of JAK2 kinase activity [ISO]
- activation of Janus kinase activity [ISO]
- activation of MAPK activity [ISO]
- allantoin metabolic process [IMP]
- cellular response to hormone stimulus [ISO]
- citrate metabolic process [IMP]
- creatine metabolic process [IMP]
- creatinine metabolic process [IMP]
- cytokine-mediated signaling pathway [IDA, ISO]
- fatty acid metabolic process [IMP]
- growth hormone receptor signaling pathway [IDA, ISO]
- hormone-mediated signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- isoleucine metabolic process [IMP]
- multicellular organismal metabolic process [ISO]
- negative regulation of neuron death [ISO]
- oxaloacetate metabolic process [IMP]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of multicellular organism growth [IDA]
- response to estradiol [ISO]
- succinate metabolic process [IMP]
- taurine metabolic process [IMP]
- valine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- cytoplasm [ISO]
- extracellular space [ISO]
- extrinsic component of membrane [IDA]
- growth hormone receptor complex [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [ISO]
- mitochondrion [ISO]
- neuronal cell body [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
SIRPA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association.
SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. Here we examine whether SIRPalpha and SHP-2 are signaling molecules for the receptors for growth hormone (GH), leukemia inhibitory factor (LIF), or interferon-gamma (IFNgamma), cytokine receptor superfamily members that bind to and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID