PTPN11
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- glycogen metabolic process [IMP]
- interleukin-27-mediated signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- leukemia inhibitory factor signaling pathway [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of interleukin-6-mediated signaling pathway [ISO]
- oncostatin-M-mediated signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of Notch signaling pathway [IDA]
- response to cytokine [ISO]
- signal transduction [IDA]
- triglyceride mobilization [ISO]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- cell body [IDA]
- ciliary neurotrophic factor receptor complex [ISO]
- cytosol [ISO]
- dendrite [IDA]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- interleukin-6 receptor complex [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- neuronal cell body membrane [ISO]
- oncostatin-M receptor complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association.
SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. Here we examine whether SIRPalpha and SHP-2 are signaling molecules for the receptors for growth hormone (GH), leukemia inhibitory factor (LIF), or interferon-gamma (IFNgamma), cytokine receptor superfamily members that bind to and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID