BAIT
MAGEF1
melanoma antigen family F, 1
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
MMS19
MET18, MMS19L, hMMS19, RP11-452K12.5
MMS19 nucleotide excision repair homolog (S. cerevisiae)
GO Process (11)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA metabolic process [IMP]
- DNA repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome segregation [IMP]
- iron-sulfur cluster assembly [IMP]
- nucleotide-excision repair [NAS, TAS]
- phosphorelay signal transduction system [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- response to hormone [NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase.
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway functions to incorporate inorganic Fe-S cofactors into a variety of proteins, including several DNA repair enzymes. However, the mechanisms regulating the CIA pathway are unknown. We describe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ubiquitination and degradation of the CIA-targeting protein MMS19. Overexpression or knockout of MAGE-F1 ... [more]
Mol. Cell Dec. 04, 2017; 69(1);113-125.e6 [Pubmed: 29225034]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MAGEF1 MMS19 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID