BAIT

APC

xapc
adenomatous polyposis coli
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis
PREY

AP2M1

adaptor-related protein complex 2, mu 1 subunit
Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.

Matsui C, Kaieda S, Ikegami T, Mimori-Kiyosue Y

The adenomatous polyposis coli (APC) tumor suppressor protein is a multifunctional protein with a well characterized role in the Wnt signal transduction pathway and in cytoskeletal regulation. The SAMP repeats region of APC, an Axin-binding site, is known to be important for tumor suppression and for the developmental function of APC. We performed a yeast two-hybrid screening using the first ... [more]

J. Biol. Chem. Nov. 21, 2008; 283(47);33006-20 [Pubmed: 18786926]

Throughput

  • Low Throughput

Curated By

  • BioGRID