MAP3K7
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- JNK cascade [IDA, TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [NAS, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [IDA, TAS]
- activation of MAPKK activity [IDA]
- activation of NF-kappaB-inducing kinase activity [IMP]
- histone H3 acetylation [IDA]
- innate immune response [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of interleukin-2 production [IMP]
- stress-activated MAPK cascade [IDA, TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOTCH2
Gene Ontology Biological Process
- Notch signaling pathway [IC, TAS]
- atrial septum morphogenesis [ISO]
- bone remodeling [ISO]
- cell cycle arrest [ISO]
- cell fate determination [ISO, TAS]
- cell growth [ISO]
- ciliary body morphogenesis [IMP]
- defense response to bacterium [IMP]
- determination of left/right symmetry [IMP]
- embryonic limb morphogenesis [IGI]
- heart looping [IGI]
- humoral immune response [IGI]
- in utero embryonic development [IMP]
- inflammatory response to antigenic stimulus [IGI]
- interleukin-4 secretion [IGI]
- left/right axis specification [IGI]
- morphogenesis of an epithelial sheet [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- organ morphogenesis [TAS]
- placenta blood vessel development [IMP]
- placenta development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell proliferation [IMP]
- positive regulation of osteoclast differentiation [IDA]
- pulmonary valve morphogenesis [ISO]
- wound healing [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.
Tuberculosis, caused by Mycobacterium tuberculosis infection, remains a global threat to human health, but knowledge of the molecular mechanisms underlying the pathogenesis of tuberculosis is still limited. Although Notch4, a member of the Notch receptor family, is involved in the initiation of mammary tumors, its function in M. tuberculosis infection remains unclear. In this study, we found that Notch4-deï¬cient mice ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of MAP3K7 not clear
Curated By
- BioGRID