BAIT
RC3H2
MNAB, RNF164, RP11-163B6.3
ring finger and CCCH-type domains 2
GO Process (1)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS27L
ribosomal protein S27-like
GO Process (7)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- DNA repair [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cellular response to DNA damage stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- mitotic G1 DNA damage checkpoint [IMP]
- positive regulation of translation [IDA]
- translation [IDA]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.
Protein phosphorylation regulates a variety of cellular signaling pathways and fundamental mechanisms in cells. In this paper, we demonstrate that the mRNA decay factor Roquin2 is phosphorylated at tyrosine residue in position 691 in vivo. This phosphorylation disrupts the interaction with KLHL6, the E3 ligase for Roquin2. Furthermore, we establish that the tyrosine phosphatase PTPN14 specifically interacts with Roquin2 through ... [more]
Cell Cycle Sep. 14, 2018; 17(18);2243-2255 [Pubmed: 30209976]
Throughput
- High Throughput
Curated By
- BioGRID