BAIT
RC3H2
MNAB, RNF164, RP11-163B6.3
ring finger and CCCH-type domains 2
GO Process (1)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PES1
PES
pescadillo ribosomal biogenesis factor 1
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- cell proliferation [IMP, NAS]
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- rRNA processing [IMP]
- regulation of cell cycle [IMP]
- ribosomal large subunit biogenesis [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.
Protein phosphorylation regulates a variety of cellular signaling pathways and fundamental mechanisms in cells. In this paper, we demonstrate that the mRNA decay factor Roquin2 is phosphorylated at tyrosine residue in position 691 in vivo. This phosphorylation disrupts the interaction with KLHL6, the E3 ligase for Roquin2. Furthermore, we establish that the tyrosine phosphatase PTPN14 specifically interacts with Roquin2 through ... [more]
Cell Cycle Sep. 14, 2018; 17(18);2243-2255 [Pubmed: 30209976]
Throughput
- High Throughput
Curated By
- BioGRID