SLC2A4
Gene Ontology Biological Process
- amylopectin biosynthetic process [IDA]
- brown fat cell differentiation [IDA]
- cation transmembrane transport [TAS]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [IDA, ISO]
- cellular response to osmotic stress [IDA]
- glucose homeostasis [ISO]
- glucose transport [IDA, ISO, TAS]
- hexose transmembrane transport [IDA]
- proton transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- cell surface [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [ISO]
- cytoplasmic vesicle membrane [IDA, TAS]
- cytosol [IDA]
- endomembrane system [IDA]
- endosome [IDA, ISO]
- external side of plasma membrane [ISO]
- extracellular vesicular exosome [IDA]
- insulin-responsive compartment [IDA, ISO]
- integral component of membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, ISO]
- membrane raft [IDA]
- multivesicular body [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
- trans-Golgi network transport vesicle [IDA]
- vesicle [ISO]
- vesicle membrane [ISO]
KIF5B
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- axon guidance [IBA]
- cytoplasm organization [IMP]
- metabolic process [ISO]
- microtubule-based process [TAS]
- mitochondrial transport [TAS]
- plus-end-directed vesicle transport along microtubule [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of synaptic transmission, GABAergic [IDA]
- protein localization [IBA]
- regulation of membrane potential [ISO]
- stress granule disassembly [IMP]
- vesicle transport along microtubule [IGI, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes.
Insulin stimulates the exocytic translocation of specialized vesicles in adipocytes, which inserts GLUT4 glucose transporters into the plasma membrane to enhance glucose uptake. Previous results support a model in which TUG (Tether containing a UBX domain for GLUT4) proteins trap these GLUT4 storage vesicles at the Golgi matrix and in which insulin triggers endoproteolytic cleavage of TUG to translocate GLUT4. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID