ITPR1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- cellular response to cAMP [ISO]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- inositol phosphate-mediated signaling [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- negative regulation of calcium-mediated signaling [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- post-embryonic development [IMP]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- response to hypoxia [IDA, ISO]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
- calcineurin complex [IDA]
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- dendrite [ISO]
- endoplasmic reticulum [IGI, TAS]
- endoplasmic reticulum membrane [IDA, ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nuclear envelope [IDA, ISO]
- nuclear inner membrane [IDA]
- nucleolus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- platelet dense granule membrane [ISO]
- platelet dense tubular network [ISO]
- postsynaptic density [IDA, ISO]
- protein complex [IPI, ISO]
- sarcoplasmic reticulum [IDA, ISO]
- secretory granule membrane [ISO]
- synaptic membrane [ISO]
RNF170
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding.
The erlin1/2 complex is a ∼2-MDa endoplasmic reticulum membrane-located ensemble of the ∼40-kDa type II membrane proteins erlin1 and erlin2. The best defined function of this complex is to mediate the ubiquitination of activated inositol 1,4,5-trisphosphate receptors (IP3Rs) and their subsequent degradation. However, it remains unclear how mutations of the erlin1/2 complex affect its cellular function and cause cellular dysfunction ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITPR1 RNF170 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID