BAIT
UBC
HMG20
ubiquitin C
GO Process (75)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA repair [TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Notch receptor processing [TAS]
- Notch signaling pathway [TAS]
- RNA metabolic process [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- carbohydrate metabolic process [TAS]
- cellular response to hypoxia [TAS]
- cytokine-mediated signaling pathway [TAS]
- endosomal transport [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- glucose metabolic process [TAS]
- glycogen biosynthetic process [TAS]
- innate immune response [TAS]
- intracellular transport of virus [TAS]
- ion transmembrane transport [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- negative regulation of type I interferon production [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of type I interferon production [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of type I interferon production [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- transmembrane transport [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HES1
HES-1, HHL, HRY, bHLHb39
hes family bHLH transcription factor 1
GO Process (32)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling pathway [IDA, IMP, TAS]
- STAT protein import into nucleus [ISS]
- artery morphogenesis [ISS]
- ascending aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- embryonic heart tube morphogenesis [ISS]
- endocrine pancreas development [TAS]
- forebrain radial glial cell differentiation [ISS]
- negative regulation of forebrain neuron differentiation [ISS]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of pro-B cell differentiation [IMP]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neuronal stem cell maintenance [IEP]
- outflow tract morphogenesis [ISS]
- pharyngeal arch artery morphogenesis [ISS]
- positive regulation of DNA binding [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of mitotic cell cycle, embryonic [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein complex assembly [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- thymus development [ISS]
- vascular smooth muscle cell development [ISS]
- ventricular septum development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [ISS]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity.
The Hairy Enhancer of Split 1 (HES1) is a transcriptional repressor that regulates cellular proliferation and differentiation during development. We previously found an interaction between HES1 and Fanconi anemia (FA) proteins. FA is a hematological and developmental disorder caused by mutations in more than 20 different genes. Eight FA gene products form a nuclear core complex containing E3 ligase activity ... [more]
BMC Res Notes Feb. 20, 2018; 11(1);138 [Pubmed: 29463306]
Throughput
- Low Throughput
Curated By
- BioGRID