BAIT
OGG1
Mmh
8-oxoguanine DNA-glycosylase 1
GO Process (10)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IMP, ISO]
- DNA repair [IGI, IMP]
- aging [ISO]
- base-excision repair [IDA, IMP, ISO]
- negative regulation of apoptotic process [ISO]
- regulation of protein import into nucleus, translocation [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to estradiol [ISO]
- response to oxidative stress [ISO]
- response to radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mitochondrion [IDA, IMP, ISO]
- nuclear matrix [ISO]
- nuclear speck [ISO]
- nucleoplasm [ISO]
- nucleus [IMP, ISO]
Mus musculus
PREY
SP3
D130027J01Rik
trans-acting transcription factor 3
GO Process (23)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- definitive hemopoiesis [IGI]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic placenta development [IGI]
- embryonic process involved in female pregnancy [IGI]
- embryonic skeletal system development [IGI]
- enucleate erythrocyte differentiation [IGI]
- erythrocyte differentiation [IMP]
- granulocyte differentiation [IMP]
- in utero embryonic development [IGI]
- liver development [IGI]
- lung development [IGI]
- megakaryocyte differentiation [IGI]
- monocyte differentiation [IMP]
- natural killer cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- ossification [IGI]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [ISO, TAS]
- transcription from RNA polymerase II promoter [ISO]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function
- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).
Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine base lesions generated by reactive oxygen species. Here we report a novel interaction between OGG1 and Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA-damage sensor protein involved in DNA repair and many other cellular processes. We found that OGG1 binds directly to PARP-1 through the ... [more]
J. Biol. Chem. Dec. 30, 2011; 286(52);44679-90 [Pubmed: 22057269]
Throughput
- Low Throughput
Curated By
- BioGRID