BAIT
OGG1
Mmh
8-oxoguanine DNA-glycosylase 1
GO Process (10)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IMP, ISO]
- DNA repair [IGI, IMP]
- aging [ISO]
- base-excision repair [IDA, IMP, ISO]
- negative regulation of apoptotic process [ISO]
- regulation of protein import into nucleus, translocation [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to estradiol [ISO]
- response to oxidative stress [ISO]
- response to radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mitochondrion [IDA, IMP, ISO]
- nuclear matrix [ISO]
- nuclear speck [ISO]
- nucleoplasm [ISO]
- nucleus [IMP, ISO]
Mus musculus
PREY
ARHGEF2
AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [IPI, ISO]
- cell morphogenesis [IDA, ISO]
- cellular response to muramyl dipeptide [ISO]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of microtubule depolymerization [ISO]
- negative regulation of neurogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [IDA, ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rho protein signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).
Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine base lesions generated by reactive oxygen species. Here we report a novel interaction between OGG1 and Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA-damage sensor protein involved in DNA repair and many other cellular processes. We found that OGG1 binds directly to PARP-1 through the ... [more]
J. Biol. Chem. Dec. 30, 2011; 286(52);44679-90 [Pubmed: 22057269]
Throughput
- Low Throughput
Curated By
- BioGRID