BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CSK
AW212630
c-src tyrosine kinase
GO Process (25)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- adherens junction organization [IBA]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [ISO]
- central nervous system development [IBA]
- innate immune response [IBA]
- intracellular signal transduction [TAS]
- morphogenesis of an epithelium [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of Golgi to plasma membrane protein transport [ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of kinase activity [ISO]
- negative regulation of low-density lipoprotein particle clearance [ISO]
- negative regulation of phagocytosis [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of MAP kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- regulation of Fc receptor mediated stimulatory signaling pathway [IBA, ISO]
- regulation of T cell activation [TAS]
- regulation of cytokine production [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID