BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HCFC1
AW060991, HCF, HCF1, RP23-252M19.5
host cell factor C1
GO Process (12)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- histone H4-K16 acetylation [ISO]
- histone H4-K5 acetylation [ISO]
- histone H4-K8 acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- regulation of protein complex assembly [ISO]
- regulation of transcription, DNA-templated [ISO]
- release from viral latency [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- transcription coactivator activity [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- transcription coactivator activity [ISO, TAS]
Gene Ontology Cellular Component
- Ada2/Gcn5/Ada3 transcription activator complex [ISO]
- MLL1 complex [ISO]
- MLL5-L complex [ISO]
- SAGA-type complex [ISO]
- Set1C/COMPASS complex [ISO]
- axon [ISO]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- histone acetyltransferase complex [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID