BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ITPR3
Ip3r3, Itpr-3
inositol 1,4,5-triphosphate receptor 3
GO Process (15)
GO Function (8)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- cellular response to cAMP [ISO]
- inositol phosphate-mediated signaling [IDA, ISO]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- response to calcium ion [ISO]
- sensory perception of bitter taste [IMP]
- sensory perception of sweet taste [IMP]
- sensory perception of umami taste [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical part of cell [ISO]
- brush border [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [IDA, ISO]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nuclear outer membrane [ISO]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID