BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KRAS
AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras, RP24-359O2.1
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
GO Process (18)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IGI]
- Ras protein signal transduction [IGI, TAS]
- actin cytoskeleton organization [IGI]
- cytokine-mediated signaling pathway [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA, IGI]
- negative regulation of cell differentiation [IDA]
- negative regulation of neuron apoptotic process [IGI]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac protein signal transduction [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of synaptic transmission, GABAergic [IGI]
- striated muscle cell differentiation [IGI]
- visual learning [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID