BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARHGEF2
AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [IPI, ISO]
- cell morphogenesis [IDA, ISO]
- cellular response to muramyl dipeptide [ISO]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of microtubule depolymerization [ISO]
- negative regulation of neurogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [IDA, ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rho protein signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID