BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LYN
AA407514, Hck-2, p53Lyn, p56Lyn, RP23-49A12.2
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
GO Process (66)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- B cell receptor signaling pathway [IDA]
- Fc receptor mediated inhibitory signaling pathway [IMP]
- Fc receptor mediated stimulatory signaling pathway [IMP]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- central nervous system development [IBA]
- chemotaxis [IBA]
- cytokine secretion [ISO]
- dendritic cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- hemoglobin biosynthetic process [TAS]
- hemopoiesis [IMP]
- histamine secretion by mast cell [ISO]
- immune response-regulating cell surface receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of B cell proliferation [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of intracellular signal transduction [IMP]
- negative regulation of mast cell proliferation [IMP]
- negative regulation of myeloid leukocyte differentiation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of toll-like receptor 2 signaling pathway [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- neuron projection development [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- platelet degranulation [IMP]
- positive regulation of B cell receptor signaling pathway [IGI]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [IMP]
- protein autophosphorylation [IDA, ISO, TAS]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IMP]
- regulation of B cell receptor signaling pathway [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [IMP]
- regulation of cytokine secretion [IMP]
- regulation of erythrocyte differentiation [IMP]
- regulation of inflammatory response [IMP]
- regulation of mast cell activation [IMP]
- regulation of mast cell degranulation [IMP]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI, ISO]
- response to hormone [IDA]
- signal transduction [TAS]
- tolerance induction to self antigen [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [IPI]
- enzyme binding [ISO]
- erythropoietin receptor binding [TAS]
- gamma-tubulin binding [ISO]
- glycosphingolipid binding [ISO]
- integrin binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI, ISO]
- protein kinase activity [IDA]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IBA, ISO]
- ubiquitin protein ligase binding [ISO]
- SH3 domain binding [IPI]
- enzyme binding [ISO]
- erythropoietin receptor binding [TAS]
- gamma-tubulin binding [ISO]
- glycosphingolipid binding [ISO]
- integrin binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI, ISO]
- protein kinase activity [IDA]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IBA, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [IMP]
- cell-cell adherens junction [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [ISO]
- mast cell granule [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrial membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID