BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PCM1
2600002H09Rik, 9430077F19Rik, C030044G17Rik
pericentriolar material 1
GO Process (11)
GO Function (1)
GO Component (10)
Gene Ontology Biological Process
- centrosome organization [ISO]
- cilium assembly [ISO]
- cytoplasmic microtubule organization [ISO]
- interkinetic nuclear migration [IMP]
- intraciliary transport involved in cilium morphogenesis [ISO]
- microtubule anchoring [IMP]
- microtubule anchoring at centrosome [IMP]
- negative regulation of neurogenesis [IMP]
- neuronal stem cell maintenance [IMP]
- positive regulation of intracellular protein transport [ISO]
- protein localization to centrosome [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID