BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MED1
AI480703, CRSP210, DRIP205, PBP, Pparbp, TRAP220, l11Jus15, RP23-333M1.1
mediator complex subunit 1
GO Process (63)
GO Function (25)
GO Component (8)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISO]
- androgen biosynthetic process [ISO]
- androgen receptor signaling pathway [ISO]
- angiogenesis [IMP]
- brain development [IMP]
- camera-type eye development [IMP]
- cell morphogenesis [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to steroid hormone stimulus [ISO]
- cellular response to thyroid hormone stimulus [ISO]
- embryonic heart tube development [IMP]
- embryonic hemopoiesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic placenta development [IMP]
- enucleate erythrocyte development [IMP]
- epithelial cell proliferation involved in mammary gland duct elongation [IMP]
- erythrocyte development [IMP]
- fat cell differentiation [IMP, ISO]
- heart development [IMP]
- in utero embryonic development [IMP]
- intracellular steroid hormone receptor signaling pathway [ISO]
- keratinocyte differentiation [ISO]
- lactation [IMP]
- lens development in camera-type eye [IMP]
- liver development [IMP]
- mRNA transcription from RNA polymerase II promoter [IMP]
- mammary gland branching involved in pregnancy [IMP]
- mammary gland branching involved in thelarche [IMP]
- mammary gland epithelial cell proliferation [IMP]
- megakaryocyte development [IMP]
- monocyte differentiation [IMP]
- multicellular organismal development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of neuron differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- organ morphogenesis [IMP]
- organ regeneration [IMP]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- positive regulation of G0 to G1 transition [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of hepatocyte proliferation [IMP]
- positive regulation of interferon-gamma-mediated signaling pathway [IMP]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of mammary gland epithelial cell proliferation [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- positive regulation of receptor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein ubiquitination [ISO]
- regulation of RNA biosynthetic process [ISO]
- regulation of transcription from RNA polymerase I promoter [ISO]
- regulation of transcription, DNA-templated [IDA, IMP, TAS]
- regulation of vitamin D receptor signaling pathway [IMP]
- retinal pigment epithelium development [IMP]
- thyroid hormone generation [IMP]
- thyroid hormone mediated signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IC]
- transcription initiation from RNA polymerase II promoter [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- LBD domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- mediator complex binding [ISO]
- nuclear hormone receptor binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA, ISO]
- receptor activity [ISO]
- retinoic acid receptor binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IMP]
- thyroid hormone receptor binding [ISO]
- thyroid hormone receptor coactivator activity [ISO]
- transcription coactivator activity [IDA, ISO, TAS]
- transcription cofactor activity [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase activity [ISO]
- vitamin D receptor binding [ISO]
- DNA binding [IDA]
- LBD domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- mediator complex binding [ISO]
- nuclear hormone receptor binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA, ISO]
- receptor activity [ISO]
- retinoic acid receptor binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IMP]
- thyroid hormone receptor binding [ISO]
- thyroid hormone receptor coactivator activity [ISO]
- transcription coactivator activity [IDA, ISO, TAS]
- transcription cofactor activity [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase activity [ISO]
- vitamin D receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID