BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRIM27
AW538890, Gm19403, Rfp
tripartite motif-containing 27
GO Process (17)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [ISO]
- innate immune response [IDA, ISO]
- interferon-gamma secretion [ISO]
- negative regulation of adaptive immune response [ISO]
- negative regulation of calcium ion import [ISO]
- negative regulation of gene expression, epigenetic [ISO]
- negative regulation of interleukin-2 secretion [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of tumor necrosis factor production [ISO]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA, ISO]
- positive regulation of actin nucleation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein K63-linked ubiquitination [ISO]
- protein trimerization [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID