BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SP1
1110003E12Rik, AA450830, AI845540, Sp1-1
trans-acting transcription factor 1
GO Process (18)
GO Function (20)
GO Component (4)
Gene Ontology Biological Process
- definitive hemopoiesis [IGI]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic placenta development [IGI]
- embryonic process involved in female pregnancy [IGI]
- embryonic skeletal system development [IGI]
- enucleate erythrocyte differentiation [IGI]
- in utero embryonic development [IGI]
- liver development [IGI]
- lung development [IGI]
- megakaryocyte differentiation [IGI]
- ossification [IGI]
- positive regulation by host of viral transcription [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IMP, ISO]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA, ISO, ISS]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- bHLH transcription factor binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- enhancer binding [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO, ISS]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- bHLH transcription factor binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- enhancer binding [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID